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肢端型黑色素瘤（acral melanoma, AM）是一种起源于手掌、足底和甲下等部位的恶性皮肤肿瘤，也是亚洲人群中最主要的黑色素瘤亚型。原位AM（AM in situ, AMis）突破基底膜进入真皮发展为侵袭性AM（invasive AM, iAM）是造成患者预后变差的重要里程碑事件。然而，目前关于AMis的研究仍然十分有限，AMis向iAM的演化过程尚不清楚，免疫微环境在这一过程中发挥的作用...
肠道微生物与宿主之间互惠共生，密不可分，定植在宿主体内的共生微生物可以通过多种机制影响宿主生理与病理生理功能。其中，胆汁酸是沟通宿主与肠道微生物的关键信使分子。初级胆汁酸，如：胆酸（CA）和鹅去氧胆酸（CDCA）在人体肝脏中合成而来，并经由胆囊进入肠道，被肠道微生物代谢为脱氧胆酸（DCA）、石胆酸（LCA）等次级胆汁酸。胆汁酸可以通过调控法尼醇X受体（FXR）、胆汁酸G蛋白偶联受体5(TGR5)、...
肝癌是中国高发恶性肿瘤。由于其广泛的肿瘤异质性，最新的靶向联合免疫治疗的方案仅对20~30%的患者有效，并且缺乏指导精准用药的药敏分子分型。因此亟需研究可以指导肝癌精准用药的分子分型和揭示新的耐药靶点。
Kalancho? PPC1 is Essential for Crassulacean Acid Metabolism and the Regulation of Core Circadian Clock and Guard Cell Signaling Genes
Crassulacean acid metabolism (CAM) plants oxaloacetate phosphoenolpyruvate carboxylase circadian clock
2024/1/22
Unlike C3 plants, Crassulacean acid metabolism (CAM) plants fix CO2 in the dark using phosphoenolpyruvate carboxylase (PPC; EC 4.1.1.31). PPC combines PEP with CO2 (as HCO3-), forming oxaloacetate tha...
Persulfidation-based Modification of Cysteine Desulfhydrase and the NADPH Oxidase RBOHD Controls Guard Cell Abscisic Acid Signaling
Abscisic Acid Signaling NADPH oxidase Persulfidation Guard cells
2024/1/22
Accumulating evidence suggests that hydrogen sulfide (H2S) is a gaseous signaling molecule that regulates diverse cellular signaling pathways through persulfidation, which involves the post translatio...
The lncRNA APOLO interacts with the transcription factor WRKY42 to trigger root hair cell expansion in response to cold
root hairs cell expansion long noncoding RNAs APOLO transcription factors RHD6 43 WRKY42 cold temperature
2023/12/8
Plant long noncoding RNAs (lncRNAs) have emerged as important regulators of chromatin dynamics, impacting on transcriptional programs leading to different developmental outputs. The lncRNA AUXIN REGUL...
近日，空军军医大学唐都医院心血管内科李妍教授团队在生物医学领域权威期刊《Cell Death＆Differentiation》（IF：12.4，JCR：Q1，中科院分区：1区）发表题为 《Lipid overload-induced RTN3 activation leads to cardiac dysfunction by promoting lipid droplet biogenesis》...
Live single-cell transcriptional dynamics via RNA labelling during the phosphate response in plants
RNA single-cell transcriptional dynamics phosphate response plant development
2023/12/1
Plants are constantly adapting to ambient fluctuations through spatial and temporal transcriptional responses. Here, we implemented the latest-generation RNA imaging system and combined it with microf...
Single-cell transcriptomics sheds light on the identity and metabolism of developing leaf cells
Single-cell transcriptomics photosynthetic Arabidopsis thaliana high-throughput transcriptome metabolic stress-related
2023/11/30
As the main photosynthetic instruments of vascular plants, leaves are crucial and complex plant organs. A strict organization of leaf mesophyll and epidermal cell layers orchestrates photosynthesis an...
CRISPR/Cas9-mediated P-CR domain-specific engineering of CESA4 heterodimerization capacity alters cell wall architecture and improves saccharification efficiency in poplar
cellulose；CESA4 homo/ heterodimerization；CRISPR/Cas9 Populus；saccharification secondary；cell wall
2023/11/30
Cellulose is the most abundant unique biopolymer in nature with widespread applications in bioenergy and high-value bioproducts. The large transmembrane-localized cellulose synthase (CESA) complexes (...
非酒精性脂肪性肝病(NAFLD)包括从单纯脂肪变性到非酒精性脂肪性肝炎(NASH)等不同严重程度的肝脏病变，而NASH可发展为肝硬化并最终发展为肝细胞癌，是当前全球肝移植和肝脏相关死亡率的主要因素之一。然而，目前还没有药物被批准用于非酒精性脂肪肝的临床治疗。肝脏中脂肪酸从头合成(DNL)速率的增加是非酒精性脂肪性肝病的一个显著特征。先前的研究表明，抑制脂肪酸从头合成中的限速酶乙酰辅酶a羧化酶(AC...
深圳大学医学部常港副教授团队在《Nature Cell Biology》发表研究论文揭示人类精子发生过程中的全局性DNA去甲基化参与减数分裂重组的调控（图）
常港副教授 深圳大学 甲基化 精子
2023/10/23
精子发生是雄性配子产生的基础，这一发育过程受到精密调控。基因突变或表观遗传变异均能够影响精子发生，进而导致雄性不育。解析人类精子发生过程中的细胞命运调控机制，对于实现人类精子的体外再生，以及男性不育疾病的临床诊断和治疗具有重要意义。医学部常港副教授团队主要聚焦于生殖细胞发育和再生的研究。2018年，常港副教授团队联合赵小阳团队、乔杰院士团队和汤富酬团队，在世界上首次揭示了人类精子发生中的细胞命运转...
武汉大学药学院邓子新院士团队和芝加哥大学化学系Chuan He教授团队合作，在Cell Research（一区，IF=44.1）发表了题为“Nm-Mut-seq: abase-resolution quantitative method for mapping transcriptome-wide 2′-O-methylation”的研究论文（2023年6月15日上线）。陈黎博士是该论文的第一作者...
Electronic cigarette aerosols induce oxidative stress-dependent cell death and NF-kappa B mediated acute lung inflammation in mice
Electronic cigarette aerosol Acute lung inflammation Oxidative stress NF-κ b pathway Aldehyde
2023/6/21
Electronic cigarette (e-cigarette) use has been linked to recent acute lung injury case clusters in over 2000 patients and dozens of deaths in the United States, however, the mechanism leading to lung...
Pendent piperidinium-functionalized blend anion exchange membrane for fuel cell application
Anion exchange membrane Blend polymers Polybenzimidazole Piperidinium Inter-chain forces
2023/6/19
Alkaline anion exchange membrane fuel cell has fast cathode reactions and thus allows the use of low cost electrocatalysts. However, its practical application is hindered by the low hydroxide ion cond...