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目前,食管癌的发病率与死亡率在全球范围内均排在前列,超过一半以上的患者发生在我国,其中约90%的病理类型为食管鳞状细胞癌(esophageal squamous cell carcinoma,ESCC)。通过以往的研究发现,食管鳞癌在基因组变异和肿瘤微环境等方面均具有广泛的肿瘤异质性,而造成食管鳞癌异质性的原因尚不清楚。因此,充分了解肿瘤异质性的特征以及其形成机制将有助于指导食管鳞癌药物开发以及临...
Hereditary diffuse gastric cancer is caused by a germline mutation in the CDH1 gene. Individuals found to carry a CDH1 mutation are at a significantly increased risk of diffuse type gastric cancer, as...
The first research publication describing polyaminated compounds in cancer tissues occurred in 1958 in the Proceedings of the National Acadamy of Japan (1). In those early years, polyaminated molecule...
Angiosarcoma of the breast is a rare tumor that accounts for 0.04 % of all breast neoplasms at the third and fourth decades of life; in contrast with carcinoma, which generally arises later. Angiosarc...
Non-Hodgkin lymphoma (NHL) is one of the masquerade syndromes of malignant melanoma that can occur with two main patterns of presentations in the eye: metastatic involvement of uveal tract, and primar...

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