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RNA nanoparticle therapy stops the spread of incurable bone marrow cancer（图）
RNA 纳米颗粒疗法 骨髓癌 肿瘤治疗
2023/6/27
Multiple myeloma is an incurable bone marrow cancer that kills over 100,000 people every year. Known for its quick and deadly spread, this disease is one of the most challenging to address. As these c...
A novel combination therapy for treating vancomycin-resistant bacterial infections（图）
万古霉素 耐药细菌感染 联合疗法
2023/6/5
Researchers have developed a novel combination therapy using the anticancer agent mitoxantrone (MTX), together with an antibiotic, vancomycin, for treating bacteria that are resistant to the vancomyci...
陈永恒教授团队在国际权威期刊Signal Transduction and Targeted Therapy上发表抑癌基因p53的新进展（图）
肿瘤 蛋白质 重点实验室 陈永恒教授 p53蛋白
2023/5/26
近日，国家卫健委肿瘤蛋白质组学重点实验室在国际权威杂志Signal Transduction and Targeted Therapy（信号转导与靶向治疗，IF=38.104）发表了题为“Targeting p53 pathways: mechanisms, structures, and advances in therapy”（靶向p53通路：机制、结构和治疗的进展）的文章。第一作者为博士研究...
Signal Transduction and Targeted Therapy丨柳素玲团队等发现趋化因子CCL20通过重塑肿瘤免疫微环境促进乳腺癌进展的新机制（图）
乳腺癌 肿瘤干细胞 肿瘤恶性 生物医学研究院
2023/4/13
肿瘤微环境（tumor microenvironment，TME）在肿瘤恶性和治疗抵抗中发挥着重要作用。近年来，根据TME特点挖掘潜在靶点并开发安全有效的免疫疗法逐渐成为乳腺癌治疗的研究热点。2018年7月27日，复旦大学生物医学研究院/附属肿瘤医院柳素玲团队在PLOS Biology杂志在线发表了题为CCL20 triggered by chemotherapy hinders the ther...
中南大学基础医学院陶永光和肖德胜团队在国际期刊Signal Transduction and Targeted Therapy上发表研究成果（图）
恶性肿瘤 中南大学基础医学院 病理学 葡萄糖
2023/3/23
近日，中南大学基础医学院 肿瘤研究所研究员陶永光团队与病理学系教授肖德胜团队在国际期刊Signal Transduction and Targeted Therapy（STTT, IF=38.104）发表了题为“GPR162 activates STING dependent DNA damage pathway as a novel tumor suppressor and radiation ...
陶永光和肖德胜教授团队在国际权威期刊Signal Transduction and Targeted Therapy上发表重要研究成果（图）
病理科 肖德胜教授 靶向治疗 DNA 中南大学 湘雅医院
2023/5/26
近日，中南大学湘雅医院病理科陶永光研究员与肖德胜教授团队在国际期刊Signal Transduction and Targeted Therapy（信号转导与靶向治疗，STTT，IF=38.104）发表了题为“GPR162 activates STING dependent DNA damage pathway as a novel tumor suppressor and radiation s...
What if, in people with blinding retinal disorders, one could simply introduce into the retina healthy photoreceptor cells derived in a dish from stem cells, and restore sight?
Signal Transduction and Targeted Therapy | 宋旭教授/赵永云课题组报道核酸适配体高选择性地抑制SARS-CoV-2诱发的炎症反应（图）
四川大学 生命科学学院 冠状病毒
2024/3/5
自2019年底以来，严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2)已经在全世界范围内引起了约5.3亿人感染，导致约1800万人死亡。几乎所有感染SARS-CoV-2的死亡患者都被发现是有细胞因子风暴综合症和病毒败血症，过度的炎症反应导致死亡率的增加，因此，防止过度炎症是避免细胞因子风暴综合症的关键。然而，目前，在临床或研究中应用的抗炎药物或免疫调节剂，包括针对炎症细胞因子(sarilu...
Molecular Therapy在线发表了题为Base-edited Cynomolgus Monkeys mimic core symptoms of STXBP1 encephalopathy的研究论文。该研究由中国科学院脑科学与智能技术卓越创新中心（神经科学研究所）、上海脑科学与类脑研究中心、中科院灵长类神经生物学重点实验室孙强研究组/刘真研究组和上海科技大学黄行许研究组合作完成。该研究通...
In the summer of 2010, Bill Ludwig and Doug Olson were battling an insidious blood cancer called chronic lymphocytic leukemia (CLL). They’d both received numerous treatments, and as remaining options ...
基础医学院生物化学与分子细胞生物学系的贾浩副研究员等最近在Molecular Therapy杂志上发表了题为“LncRNA IFITM4P is activated through LPS/TLR4 and promotes immune escape by up-regulating PD-L1 via dual mechanism during oral carcinogenesis”的学术文...
牛侨教授团队在《Molecular Therapy-Nucleic Acid》发文：利用全转录组测序揭示预防和治疗铝神经毒性作用的生物靶点（图）
牛侨教授 山西医科大学 公共卫生学
2023/12/25
2021年11月，山西医科大学公共卫生学院劳动卫生学教研室牛侨教授团队在《Molecular Therapy-Nucleic Acid》（JCR1区、中科院2区，影响因子8.886）在线发表题为“Whole-transcriptome analysis of aluminum-exposed rat hippocampus and identifification of ceRNA network...
Differences in T cells’ functional states determine resistance to cancer therapy（图）
T细胞 癌症治疗 耐药性
2023/6/6
Non-small cell lung cancer (NSCLC) is the most common type of lung cancer in humans. Some patients with NSCLC receive a therapy called immune checkpoint blockade (ICB) that helps kill cancer cells by ...
‘Frameshifting’ therapy for mast cell cancers reduces size, spread
mRNA c-KIT mast cells cancer cell
2021/8/11
A potential new treatment for mast cell cancers reduces the number of mast cells by 'mutating' the messenger RNA (mRNA) before it can deliver instructions for manufacturing the gene responsible for ce...
New technology paves way towards personalized antibiotic therapy New sensor provides quick test to measure antibiotic resistance
microwave sensor antibiotics resistance bacteria
2021/8/10
Researchers have developed a method for monitoring bacterial responses to antibiotics in health-care settings that opens the door to personalized antibiotic therapy for patients. Using microwave sensi...