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心脑血管疾病(CVD)是全世界人口死亡的主要原因之一。85%的CVD相关死亡是由于心脏病发作和脑中风导致。动脉粥样硬化引发动脉管腔狭窄导致心脏病发作和脑中风。前期，中国科学院遗传与发育生物学研究所张永清研究员团队与北京希诺谷生物技术公司和首都医科大学吉训明教授等团队合作在SCIENCE CHINA Life Sciences发表了Dogs lacking Apolipoprotein E show...
The DNA in our cells constantly changes its structure and chemical composition in the course of endogenous processes and in response to exogenous challenges. The 2017 Mammalian DNA Repair GRC will exp...
Human metabolism of mammalian lignan precursors in raw and processed flaxseed
Flaxseed lignans enterodiol
2016/5/30
The mammalian lignans enterolactone and enterodiol
are produced in the colon by the action of bacteria on the
plant precursor secoisolariciresinol diglycoside, which is found
in high concentrations...
21 days of mammalian omega-3 fatty acid supplementation improves aspects of neuromuscular function and performance in male athletes compared to olive oil placebo
Omega-3 fatty acids Neuromuscular function Fat supplementation Performance Adaptations to training
2015/7/30
Omega-3 polyunsaturated fatty acids (N-3) are essential nutrients for human health and integral components of neural tissues. There is evidence that N-3 supplementation may benefit exercise performanc...
Evolution of the redox function in mammalian Apurinic/ apyrimidinic endonuclease
APE1 redox evolutionary analysis
2014/12/12
Human apurinic/apyrimidinic endonuclease (hApe1) encodes two important functional activities: an essential base excision repair (BER) activity and a redox activity that regulates expression of a numbe...
Yeast apurinic/apyrimidinic endonuclease Apn1 protects mammalian neuronal cell line from oxidative stress
DNA repair gene therapy
2014/12/12
Reactive oxygen species (ROS) have been implicated as one of the agents responsible for many neurodegenerative diseases. A critical target for ROS is DNA. Most oxidative stress-induced DNA damage in t...
Genome-wide analysis and proteomic studies reveal APE1/Ref-1 multifunctional role in mammalian cells
APE1/Ref-1 cell signaling difference analysis
2014/12/12
Apurinic apyrimidinic endonuclease/redox effector factor 1 (APE1/Ref-1) protects cells from oxidative stress by acting as a central enzyme in base excision repair pathways of DNA lesions and through i...
Hydrostatic pressure and mammalian cardiac-pacemaker function
animal mice Guinea Pig dog Rabbits Rat pacemaker cardiac
2009/7/20
Hydrostatic pressure and mammalian cardiac-pacemaker function.
Fracture studies on a mammalian semicircular canal
Venter,RD Ward,CA Ho,S Johnson,WR Fraser,WD Landolt,JP
2009/7/15
In the present work the pressures necessary to fracture the semicircular canal of the mammalian inner ear, specifically the squirrel monkey, have been investigated experimentally. The results indicate...
Technical Approach to Generate Polyclonal Antibodies Against Bacterially Expressed GST-PYK- C: Evaluation of Cross-Reaction and Recognition in Some Mammalian and Yeast Cell Lysates
pyk-2 Central Nervous System Molecular Cloning Gene Fusion Bacterial Proteins Antibody Formation Antibody Specificity Immunochemistry Immunoblot-ting
2009/7/1
Pyk-2 is a protein tyrosine kinase, highly expressed in human hippocampus, dentate gyrus and olfactory bulb. In this study, polyclonal antibodies against the C-terminal of pyk-2, starting from Pro-759...
Hydrogen gas is not oxidized by mammalian tissues under hyperbaric conditions
hyperbaric chamber
2009/6/12
Mammalian tissues, including heart, lung, liver, kidney, spleen, and skeletal muscle of guinea pig, rat, or pig, were exposed to tritium (T2) and high pressures of H2. Incorporation of the tritium lab...
'In situ' high pressure confocal Ca(2+)-fluorescence microscopy in skeletal muscle:a new method to study pressure limits in mammalian cells
high pressure microscopy in situ confocal laser scanning microscopy PRESSURE Ca2+ homeostasis mammalian skeletal muscle fluorescence mitochondria
2009/6/2
We combined 'in situ' high pressure microscopy with confocal laser scanning microscopy to directly study Ca2+ homeostasis in intact mammalian (murine) skeletal muscle fibres during high pressure expos...
Expression analysis of mammalian selenocysteine lyase
Selenium Deficiency Mouse Selenocysteine lyase Expression
2009/4/1
Selenium (Se) is an essential trace element of mammals and plays important roles in the form of selenocysteine residues in selenoproteins. Selenocysteine lyase (SCL) specifically catalyzes the decompo...
RNAi-mediated knock down of mammalian selenocysteine lyase
Selenocysteine Selenocysteine lyase Selenoprotein
2009/4/1
Selenocysteine lyase (SCL), which specifically catalyzes the decomposition of L-selenocysteine into Se and L-alanine, is proposed to function as a Se delivery protein to selenophosphate synthetase in ...
Hydrogen gas is not oxidized by mammalian tissues under hyperbaric conditions.
hyperbaric chamber
2009/3/28
Mammalian tissues, including heart, lung, liver, kidney, spleen, and skeletal muscle of guinea pig, rat, or pig, were exposed to tritium (T2) and high pressures of H2. Incorporation of the tritium lab...