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Statistical design considerations applicable to clinical trials of iodine supplementation in pregnant women who may be mildly iodine deficient
clinical trials iodine supplementation outcomes measurement pregnancy statistical methods
2018/12/14
No large, randomized, placebo-controlled trial of iodine supplementation in pregnant women in a region of mild or moderate iodine deficiency has been completed in which a primary outcome measure was a...
Ethical issues around phase I and phase III clinical trials in cancer
Cancer clinical trials clinical practice drug toxicity
2017/2/22
The results of phase III (randomised) cancer clinical trials underpin evidence-based clinical practice. A standard comparator (control arm) is crucial so that the real value of an intervention can be ...
Ethical issues around phase I and phase III clinical trials in cancer
cancer Ethical issues
2017/4/10
The results of phase III (randomised) cancer clinical trials underpin evidence-based clinical practice. A standard comparator (control arm) is crucial so that the real value of an intervention can be ...
Project Management of Randomized Clinical Trials:A Narrative Review
Clinical Trial Project Management Trial Manager Principal Investigator Study Protocol
2015/11/9
Context: A well-structured protocol for a clinical trial may be able to answer clinical questions, but it cannot be deemed enough to ensure success in the face of incompetent management of time as wel...
A Meta-Analysis of Randomized Clinical Trials Comparing Shorter (Less or Equal Than 6 Months) and Longer (More or Equal Than 12 Months) Dual Anti-Platelet Therapy Following Drug-Eluting Coronary Stents
Drug-Eluting Stents Dual Antiplatelet Therapy Meta-Analysis
2015/11/9
Context: The optimal duration of dual anti-platelet therapy (DAPT) after the implantation of drug-eluting coronary stents (DES) is still the subject of ongoing debate. This meta-analysis was performed...
Investigator initiated clinical trials are critical to the advancement of cancer care in Australia. Cooperative clinical trials
groups in Australia and New Zealand contribute greatly to independent ...
Co-operative Clinical Trials in Cancer – the need for increased capacity
increased capacity Cancer
2015/1/23
In the clinical management of cancer, the
practice of evidence based medicine is
almost totally reliant on the findings of
previous clinical trials
Botulinum Toxin Type A Therapy in Migraine:Preclinical and Clinical Trials
Botulinum Toxin Type A Nitroglycerin Randomized Controlled Trial
2015/10/9
Background: Botulinum toxin type A (BTX-A) has been reported to be effective for the therapy for migraine. The purpose of this study was to investigate the effect of BTX-A on the immunoreactive levels...
Is Certolizumab Pegol Safe and Effective in the Treatment of Patients with Moderate to Severe Crohn’s Disease? A Meta-analysis of Controlled Clinical Trials
Meta-analysis Certolizumab Pegol Crohn’s Disease
2015/10/8
Background: Tumor necrosis factor-α (TNF-α) antibodies are currently used in patients with moderate to severe Crohn’s disease (CD) who are unresponsive to conventional therapies. Certolizumab pegol (C...
Evaluation of the methodologies used in clinical trials and effectiveness of chemo-mechanical caries removal with CarisolvTM
Dental caries Effectiveness Methods
2009/10/19
This investigation aims to discuss the methodologies applied in clinical trials published about CarisolvTM, in order to assess the best scientific evidence concerning chemo-mechanical caries removal. ...
People’s experiences of taking part in clinical trials have been captured in a new section of www.healthtalkonline.org, the award-winning patient website based on Oxford University research.The online...
Carbon monoxide poisoning:interpretation of randomized clinical trials and unresolved treatment issues
outcomes HBO hyperbaric
2009/6/5
Since hyperbaric oxygen therapy (HBO2) appeared as a treatment for CO poisoning in 1960, whether and when to use it for CO poisoning have often been debated. HBO2 has been advocated to treat severe CO...
Pfizer Stops All Torcetrapib Clinical Trials in Interest of Patient Safety
Patient Safety cardiovascular
2006/12/26
On December 2, 2006, FDA was notified that Pfizer will suspend a large, Phase 3 trial evaluating the investigational cardiovascular therapy torceptrapib/atorvastatin (T/A) due to an increased rate of ...
Review of "Fundamentals of Clinical Trials" by LM. Friedman, CD. Furberg and DL. DeMets
Fundamentals of Clinical Trials LM. Friedman CD. Furberg DL. DeMets
2010/3/1
Clinical Research faces perhaps a certain grain of confusion. Often, it is mistakenly reduced to case report. Caveats of even greater risks may be hidden in the secrets of patents and interests of man...
Clinical trials: How consumers, clinicians and researchers can initiate and participate in the best cancer trial
Clinical trials consumers
2015/3/13
These are exciting times. The last 30 years have seen major
reductions in mortality from breast cancer, childhood
leukaemia and testis cancer heralding what is possible for
other cancers. These imp...