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Stimulation of the proliferation and differentiation of Leydig cell precursors after the destruction of existing Leydig cells with ethane dimethyl sulphonate（EDS）can take place in the absence of LH
proliferation differentiation Leydig cell precursors
2009/2/23
In hypophysectomized rats, 2 days after the administration of the cytotoxic drug ethane dimethyl sulphonate (EDS), the proliferative activity of Leydig cell precursors increased six-fold. Thus, fact...
Mechanism of LHRH-stimulated steroidogenesis in rat Leydig cells：lipoxygenase products of arachidonic acid may not be involved
LHRH-stimulated steroidogenesis rat Leydig cells lipoxygenase products arachidonic acid
2009/2/23
Luteinizing hormone releasing hormone agonist, [(imBzl)-DHis6,Pro9,NEt]-LHRH (LHRH-A), caused a two to threefold increase in in vitro testosterone (T) secretion by rat Leydig cells. This LHRH-A-indu...
Transplantation of newborn rat testis under the kidney capsule of adult host as a model to study the structure and function of Leydig cells
newborn rat testis kidney capsule adult host Leydig cells
2009/2/23
Newborn rat testis was transplanted under the kidney capsule of adult castrated and uncastrated male rats to develop and characterize a model system for studies on Leydig cell development. Two weeks...
It has been reported that Leydig cells have Fc receptors, which traditionally have been considered markers specific for macrophages and polymorphonuclear leukocytes. The purpose of this investigat...
Origin and fate of autophagosomes in Leydig cells of normal adult rats
Origin fate autophagosomes Leydig cells normal adult rats
2009/2/23
Autophagosomes were observed frequently in electron microscope photographs of Leydig cells from normal adult rat testis. Their formation, evolution and fate were analyzed morphologically in preparat...
Binding and internalization in vivo of [125I]hCG in Leydig cells of the rat
Binding and internalization [125I]hCG Leydig cells rat
2009/2/23
The present study was performed to demonstrate the binding, mode of uptake, pathway and fate of iodinated human chorionic gonadotropin ([125I]hCG) by Leydig cells in vivo using electron microscope...
Uptake and release of ascorbic acid by rat Leydig cells in vitro
ascorbic acid rat Leydig cells
2009/2/23
The mechanism by which ascorbic acid is transported into rat Leydig cells in vitro was investigated. Transport of [14C]ascorbic acid was temperature-dependent and inhibited in the absence of sodium ...
The effect of selective destruction and regeneration of rat Leydig cells on the intratesticular distribution of testosterone and morphology of the seminiferous epithelium
selective destruction regeneration rat Leydig cells intratesticular distribution
2009/2/23
This study was designed to explore the relationship between the intratesticular distribution of testosterone and spermatogenesis by completely destroying the Leydig cells of mature male rats with in...
Impaired estrogen production by Leydig cells of the naturally retained testis in unilaterally cryptorchid boars and stallions
testis cryptorchid boar stallion estrogens
2009/2/23
Estrogen production in vitro was compared for Leydig cells from cryptorchid and scrotal testes in boars and stallions. Animals with natural and experimental cryptorchidism were used. Purified Leydig...
Intracellular pathways of endocytosed tracers in Leydig cells of the rat
Intracellular pathways endocytosed tracers Leydig cells rat
2009/2/23
The endocytic activity of Leydig cells was examined by electron microscopy following the injection, into the interstitial space, of tracers used to examine fluid-phase endocytosis, ie, native ferrit...
Fetal irradiation increases androgen production by dispersed leydig cells of the rat
seminiferous tubule damage fetal irradiation
2009/2/20
Damage to the seminiferous epithelium of the rat has been shown to decrease the concentration of serum testosterone. In these animals, compared to controls, the structure of the Leydig cells sugge...
Effects of gossypol on rat Sertoli and Leydig cells in primary culture and established cell lines
rat Sertoli Leydig cells established cell lines
2009/2/19
In order to evaluate the direct effect of gossypol on testicular cells, we used primary cultures of rat Leydig and Sertoli cells. No alteration in Leydig cell survival, morphology, or testosterone...
Evidence for the presence of androgen receptors in purified rat Leydig cells
androgen receptors purified rat Leydig cells
2009/2/19
Leydig cells, purified on two sequential Percoll gradients to purities of 89 +/- 1%, were used to study the binding of 17-beta-hydroxy-17 alpha-methyl-estra-4,9,11-triene-3-one(3H-R1881). The accumu...
Testosterone decreases 3beta-hydroxysteroid dehydrogenase-isomerase messenger ribonucleic acid in cultured mouse Leydig cells by a strain-specific mechanism
Steroidogenesis testis inbred mice androgen
2009/2/17
We previously reported a strain-related difference in basal 3beta-hydroxysteroid dehydrogenase-isomerase (3betaHSD) activity in response to testosterone in cultured Leydig cells. The data suggested ...
The cellular mechanisms of corticotropin-releasing hormone（CRH）-stimulated steroidogenesis in mouse Leydig cells are similar to those for LH
MA-b Progesterone testosterone
2009/2/17
Previous reports have demonstrated that corticotropin-releasing hormone (CRH) treatment of primary cultures of mouse Leydig cells and MA-10 mouse Leydig tumor cells results in a dose-dependent sti...