搜索结果: 1-12 共查到“医学 Celecoxib”相关记录12条 . 查询时间(0.131 秒)
探讨选择性环氧合酶-2(COX-2)抑制剂Celecoxib联合羟基喜树碱对缺氧诱导的人肝癌细胞株SMMC-7721细胞增殖和凋亡的影响。方法：应用三气培养箱在缺氧环境下培养人肝癌细胞株SMMC-7721细胞。预实验筛选Celecoxib、羟基喜树碱最小有效终浓度，设24、48、72小时为干预时间并筛选最佳作用时间。分别以Celecoxib及羟基喜树碱单独实验筛选的最小有效浓度为联合组浓度；以Ce...
A Comparative Study on the Efficacy of Ibuprofen and Celecoxib on the Intensity of Perineal Pain Following Episiotomy:A Randomized Clinical Trial
Ibuprofen Celecoxib Episiotomy Neuralgia
2015/10/9
Background:: Pain is a worldwide problem that often originates from disease process, and diagnostic and treatment procedures such as surgical operations.
A rapid and sensitive HPLC method for the analysis of celecoxib in human plasma:application to pharmacokinetic studies
Celecoxib HPLC Pharmacokinetics Human Plasma
2009/12/18
Background and the purpose of the study: A suitable high-performance liquid chromatography (HPLC) method for determination of celecoxib levels in plasma is of prime need for the pharmacokinetics and b...
Effect of Celecoxib on Emotional Stress and Pain-Related Behaviors Evoked by Experimental Tooth Movement in the Rat
Pain Celecoxib Tooth movement Behavior
2010/3/9
Objective: To test the efficacy of an animal model of pain and stress and evaluate the effects of celecoxib administered when orthodontic force is applied.
Materials and Methods: A 20-g reciprocal fo...
Comparison of Ibuprofen,Celecoxib and Tramadol in Relief of Pain after Extraction of Mandibular Third Molar Teeth
Ibuprofen Celecoxib Tremadol Pain relief Mandibular third molar teeth
2015/9/18
Background: The ultimate goal of oral health care providers is not only to restore function, but also to relieve pain. This study was undertaken to compare the analgesic efficacy of ibuprofen, celecox...
Combined Neoadjuvant Chemotherapy and Celecoxib in Locally Advanced Breast Cancer
Neoadjuvant chemotherapy Celecoxib Locally advanced breast cancer
2015/9/18
Background: Locally advanced breast cancer is a presentation form of cancer with poor prognosis. The optimal method of treatment for these cases remains unclear. In this trial, the role of low dose ce...
Celecoxib对胃癌细胞凋亡的影响
胃癌 Celecoxib 细胞凋亡
2009/8/11
目的: 研究选择性环氧合酶-2(COX-2)抑制剂Celecoxib对人胃癌细胞株SGC7901凋亡的影响. 方法: 采用MTT法测定人胃癌细胞株SGC7901分别在1×10(-5), 1×10(-6), 1×10(-7), 1×10(-8), 1×10(-9) mol/L的Celecoxib作用48 h后生长抑制情况; 流式细胞术(FCM)观察Celecoxib 对SGC7901细胞凋亡的影响;...
目的: 探讨喜树碱类衍生物与celecoxib联合用药的体外和体内的抗肿瘤作用及机制，同时观察celecoxib对CPT-11引起裸鼠腹泻的影响. 方法: 以MTT法检测结肠癌细胞系在联合应用celecoxib后对喜树碱及其衍生物的化学敏感性的改变;流式细胞术检测celecoxib与喜树碱联合用药后HT-29细胞的凋亡比率和细胞周期的变化;Western Blot法检测环氧合酶-2(COX-2)以...
Celecoxib Enhances the Chemotherapeutic Response of Cisplatin and TNF-α in SiHa Cells through Reactive Oxygen Species-Mediated Mitochondrial Pathway
cervical cancer apoptosis celecoxib cisplatin TNF-α mitochondria
2009/4/20
Recently, many studies have shown that celecoxib induces apoptosis in various cancer cells by different mechanisms depending on the cell type. This study examined the effect of the selective COX-2 inh...
Celecoxib 在人癌裸鼠移植瘤抗癌与放射增敏的作用机制研究
celecoxib 移植瘤 放射增敏 作用机制
2014/1/15
探讨选择性环氧化酶-2 抑制剂celecoxib 抗癌及放射增敏作用的可能机制。方法 构建人宫颈癌裸鼠移植瘤模型,celecoxib 和/ 或移植瘤局部放射干预,检测移植瘤生长延缓、移植瘤组织中环氧化酶-2 与前列腺素E2 含量的变化,并分析此变化与移植瘤生长延缓的关系。结果 移植瘤最大径从8mm 生长至10mm 所需的时间,空白对照组为(4. 42 ±0. 78) d ,单纯放射组为(6. 25...
COX-2 选择性抑制剂Celecoxib 治疗胶质瘤的体内实验研究
塞来昔布 胶质瘤 抑制作用
2014/1/15
探讨选择性环氧化酶-2抑制剂Celecoxib(塞来昔布)对C6胶质瘤生长抑制的体内实验研究。方法 将成瘤小鼠分为对照组和治疗组，应用肿瘤HE染色法、肿瘤生长曲线、前列腺素E2(PGB)检测及电镜检查方法观察Celecoxib对小鼠移植瘤的作用。结果 HE染色和电镜可见治疗组血管破坏、细胞坏死和凋亡，PGE2检测及肿瘤生长曲线分析有统计学意义，P<0．05。结论 Celecoxib能够抑制COX-...
研究Celecoxib对COX 2高表达人胰腺癌细胞JF 30 5生长和凋亡的影响及作用机制。方法 采用四唑氮蓝 (MTT)比色法检测细胞增殖 ,流式细胞仪测定细胞周期和凋亡 ,酶联免疫吸附试验 (ELISA)检测前列腺素E2 (PGE2 )含量。结果 Celecoxib可明显抑制JF 30 5细胞增殖和诱导其凋亡 ,并且这种增殖抑制作用能被PGE2 拮抗。结论 Celecoxib通过COX 2和...