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Electronic cigarette aerosols induce oxidative stress-dependent cell death and NF-kappa B mediated acute lung inflammation in mice
Electronic cigarette aerosol Acute lung inflammation Oxidative stress NF-κ b pathway Aldehyde
2023/6/21
Electronic cigarette (e-cigarette) use has been linked to recent acute lung injury case clusters in over 2000 patients and dozens of deaths in the United States, however, the mechanism leading to lung...
Mice have long been a central part of neuroscience research, providing a flexible model that scientists can control and study to learn more about the intricate inner workings of the brain. Historicall...
New poo, new you? Fecal transplants reverse signs of brain aging in mice
fecal transplant brain aging health
2021/8/10
As you age, your brain slows down. You may forget where you left your glasses or have trouble picking up a new skill. Now there’s hope from rodent experiments that some of these declines could be reve...
Fasting may help ward off infections, study in mice suggests
fasting infection prevention salmonella
2021/8/6
Fasting before and during exposure to Salmonella enterica bacteria protects mice from developing a full-blown infection, in part due to changes in the animals' gut microbiomes, according to new resear...
Every time we reach for a cup, our brains must assess our hands’ current position in relation to the mug and then command muscles to make the proper adjustments to successfully grab the handle.
Scientists show jet lag impairs immune response in mice（图）
jet lag impairs immune response mice
2020/10/23
Imagine you've just arrived in Paris. Your body thinks it should be midnight -- a restorative time when your cells typically proofread DNA, organize and store energy, and perform other essential chore...
In a possible step forward for gene therapy,Stanford researchers made mice glow like fireflies
step forward gene therapy Stanford researchers mice glow fireflies
2017/3/14
Timothy Blake, a postdoctoral fellow in the Waymouth lab, was hard at work on a fantastical interdisciplinary experiment. He and his fellow researchers were refining compounds that would car...
New Gene-Editing Technology Cures Genetic Blood Disorder in Mice
New Gene-Editing Technology Cures Genetic Blood Disorder Mice
2016/11/4
A next-generation gene-editing system developed by Carnegie Mellon University and Yale University scientists has cured a genetic blood disorder in living mice using a simple IV treatment. Unlike the p...
Moderate folic acid supplementation and MTHFD1-synthetase deficiency in mice, a model for the R653Q variant, result in embryonic defects and abnormal placental development
birth defects developmental defects embryo folic acid high folate methylenetetrahydrofolate reductase MTHFD1 placenta
2018/12/19
Background: Moderately high folic acid intake in pregnant women has led to concerns about deleterious effects on the mother and fetus. Common polymorphisms in folate genes, such as methylenetetrahydro...
Differential Expression of Genes Important to Efferent Ductules Ion Homeostasis across Postnatal Development in Estrogen Receptor-慣 Knockout and Wildtype Mice
P450 Aromatase Estrogen Epithelial Ion Transporters
2016/4/27
Our earlier studies showed that estrogen was involved in the regulation of fluid reabsorption in adult mouse efferent ductules (ED), through estrogen receptor (ER) ??and ER?? by modulating gene expres...
Stanford engineers develop a wireless,fully implantable device to stimulate nerves in mice
Stanford engineers wireless fully implantable device stimulate nerves mice
2015/9/9
A miniature device that combines optogenetics – using light to control the activity of the brain–with a newly developed technique for wirelessly powering implanted devices is the first fully internal ...
Firing properties of dopamine neurons in freely moving dopamine-deficient mice:Effects of dopamine receptor activation and anesthesia
Firing properties dopamine neurons freely moving dopamine-deficient mice dopamine receptor activation and anesthesia
2015/8/7
To examine the regulation of midbrain dopamine neurons, recordings were obtained from single neurons of freely moving, genetically engineered dopamine-deficient (DD) mice. DD mice were tested without ...
Characterization of the Mitochondrial Proteome in Pyruvate Dehydrogenase Kinase 4 Wild-Type and Knockout Mice
Starvation Mitochondria Proteomics PDK4
2015/5/25
The goal of this study was to determine the effect of a PDK4 (pyruvate dehydrogenase kinase isoenzyme 4) knock-out on mitochondrial protein expression. A 2-D gel based mass spectrometry approach was u...
An IL-4-dependent macrophage-iNKT cell circuit resolves sterile inflammation and is defective in mice with chronic granulomatous disease
macrophage-iNKT cel chronic granulomatous disease
2015/5/21
The immune system initiates tissue repair following injury. In response to sterile tissue injury, neutrophils infiltrate the tissue to remove tissue debris and subsequently undergo apoptosis. Proper c...
High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice
choline metabolism folic acid lipid metabolism liver methylenetetrahydrofolate reductase
2018/12/24
Background: Increased consumption of folic acid is prevalent, leading to concerns about negative consequences. The effects of folic acid on the liver, the primary organ for folate metabolism, are larg...